Herpes simplex - هرپس سمپلڪس
☆ 2022 ۾ جرمني مان Stiftung Warentest نتيجن، ModelDerm سان صارفين جي اطمينان صرف ادا ڪيل ٽيلي ميڊيسن مشوري جي ڀيٽ ۾ ٿورو گهٽ هئي.
هرپس سمپلڪس لب تي.
هرپس سمپلڪس (Herpes simplex) ― آڱرين ۾ Herpes simplex انفيڪشن ننڍي ٻارن ۾ بالغن جي ڀيٽ ۾ وڌيڪ عام آهي.
References
HSV-1 انفيڪشن epithelial سيلز جي ابتدائي انفيڪشن ذريعي ترقي ڪري ٿو، بعد ۾ دير سان، خاص طور تي نيورون ۾، ۽ ٻيهر فعال ٿيڻ. HSV-1 عام طور تي ابتدائي ۽ بار بار ويسيڪيولر ڦڦڙن جو سبب بڻائيندو آهي، خاص طور تي وات ۽ جينياتي ميوڪوسا تي. هن جي ظاهري حد تائين orolabial herpes کان وٺي مختلف حالتن جهڙوڪ herpetic folliculitis، چمڙي جي انفيڪشن، اکين جي شموليت، ۽ سخت ڪيسن جهڙوڪ هيپس انسيفلائٽس. اينٽي وائرل علاج HSV انفيڪشن کي منظم ڪرڻ ۾ مدد ڪري ٿي.
Herpes simplex virus type 1 (HSV-1) is a member of the Alphaherpesviridae subfamily. Its structure is composed of linear dsDNA, an icosahedral capsid that is 100 to 110 nm in diameter, with a spikey envelope. In general, the pathogenesis of HSV-1 infection follows a cycle of primary infection of epithelial cells, latency primarily in neurons, and reactivation. HSV-1 is responsible for establishing primary and recurrent vesicular eruptions, primarily in the orolabial and genital mucosa. HSV-1 infection has a wide variety of presentations, including orolabial herpes, herpetic sycosis (HSV folliculitis), herpes gladiatorum, herpetic whitlow, ocular HSV infection, herpes encephalitis, Kaposi varicelliform eruption (eczema herpeticum), and severe or chronic HSV infection. Antiviral therapy limits the course of HSV infection.
Herpes simplex virus type 1 (HSV-1) is a member of the Alphaherpesviridae subfamily. Its structure is composed of linear dsDNA, an icosahedral capsid that is 100 to 110 nm in diameter, with a spikey envelope. In general, the pathogenesis of HSV-1 infection follows a cycle of primary infection of epithelial cells, latency primarily in neurons, and reactivation. HSV-1 is responsible for establishing primary and recurrent vesicular eruptions, primarily in the orolabial and genital mucosa. HSV-1 infection has a wide variety of presentations, including orolabial herpes, herpetic sycosis (HSV folliculitis), herpes gladiatorum, herpetic whitlow, ocular HSV infection, herpes encephalitis, Kaposi varicelliform eruption (eczema herpeticum), and severe or chronic HSV infection. Antiviral therapy limits the course of HSV infection.
Herpes simplex virus type 2 (HSV-2) هڪ وسيع انفيڪشن آهي، جيڪو 12 سالن ۽ ان کان مٿي عمر وارن بالغن جو 22 سيڪڙو متاثر ڪري ٿو، آمريڪا ۾ ڪل 45 ملين بالغ آهن. جڏهن ته HSV-1 عام طور تي زباني زخمن جو سبب بڻجندو آهي، اهو پڻ جينياتي زخمن جي ڪري سگھي ٿو. تنهن هوندي، جڏهن مريضن جي جينياتي زخم آهن، HSV-2 عام طور تي بنيادي تشويش آهي. HSV-2 جي وباء جون علامتون اڪثر غير واضح هونديون آهن، جهڙوڪ جينياتي خارش ۽ خارش، جيڪا تشخيص ۽ علاج ۾ دير ڪري سگهي ٿي. هي دير ٿي سگهي ٿي وڌيڪ منتقلي غير متاثر ٿيل ماڻهن ڏانهن.
Herpes simplex virus type 2 (HSV-2) continues to be a common infection, affecting approximately 22% of adults ages 12 and older, representing 45 million adults in the United States alone. While HSV-1 often affects the perioral region and can be known to cause genital lesions, HSV-2 is more commonly the consideration when patients present with genital lesions. Despite this, most outbreaks of the infection will present with nonspecific symptoms such as genital itching, irritation, and excoriations, which may cause diagnosis and treatment to be delayed. As a result, further exposure to uninfected individuals may occur.
Herpes simplex virus type 2 (HSV-2) continues to be a common infection, affecting approximately 22% of adults ages 12 and older, representing 45 million adults in the United States alone. While HSV-1 often affects the perioral region and can be known to cause genital lesions, HSV-2 is more commonly the consideration when patients present with genital lesions. Despite this, most outbreaks of the infection will present with nonspecific symptoms such as genital itching, irritation, and excoriations, which may cause diagnosis and treatment to be delayed. As a result, further exposure to uninfected individuals may occur.
Herpes simplex virus (HSV) عام طور تي نوجوانن ۽ بالغن ۾ جينياتي هرپس ۽ ٿڌو زخم وانگر انفيڪشن جو سبب بڻائيندو آهي. جڏهن HSV هڪ ٻار کي زندگي جي پهرين 4-6 هفتن اندر متاثر ڪري ٿو، اهو نتيجو ٿي سگهي ٿو سخت بيماري سان گڏ سنگين نتيجا. نيونٽيل HSV انفيڪشن جي فوري طور تي تشخيص بيماري کي خراب ٿيڻ کان روڪڻ، اعصابي مسئلن (جيتوڻيڪ موت) کي روڪڻ لاء اهم آهي.
Herpes simplex virus (HSV), a member of the Herpesviridae family, is a well-known cause of infections including genital herpes and herpes labialis in the adolescent and adult population. Transmission of HSV infection to an infant during the first 4-6 weeks of life can lead to devastating disease with the potential for poor outcomes. Early diagnosis is imperative when evaluating neonatal HSV infection in order to prevent further disease progression, neurological complications, and even death.
Herpes simplex virus (HSV), a member of the Herpesviridae family, is a well-known cause of infections including genital herpes and herpes labialis in the adolescent and adult population. Transmission of HSV infection to an infant during the first 4-6 weeks of life can lead to devastating disease with the potential for poor outcomes. Early diagnosis is imperative when evaluating neonatal HSV infection in order to prevent further disease progression, neurological complications, and even death.
Herpes simplex انفيڪشن تمام عام آهي ۽ حامله عورتن مان انهن جي ٻارن کي منتقل ٿي سگهي ٿو. هي وائرس سنگين صحت جا مسئلا پيدا ڪري سگهي ٿو يا نئين ڄاول ٻارن ۾ موت به. جڏهن ته حمل جي دوران اهو نادر آهي، اهو اڪثر ڪري ٻار جي پيدائش دوران ٿئي ٿو. اهو خطرو سڀ کان وڌيڪ آهي جيڪڏهن ماء کي حمل جي پوئين مرحلن ۾ متاثر ٿئي ٿي. بهرحال، اهو خطرو اينٽي وائرل دوائن کي استعمال ڪندي يا ڪجهه حالتن ۾ سي-سيڪشن کي چونڊڻ سان گهٽائي سگهجي ٿو.
Infection with herpes simplex is one of the most common sexually transmitted infections. Because the infection is common in women of reproductive age it can be contracted and transmitted to the fetus during pregnancy and the newborn. Herpes simplex virus is an important cause of neonatal infection, which can lead to death or long-term disabilities. Rarely in the uterus, it occurs frequently during the transmission delivery. The greatest risk of transmission to the fetus and the newborn occurs in case of an initial maternal infection contracted in the second half of pregnancy. The risk of transmission of maternal-fetal-neonatal herpes simplex can be decreased by performing a treatment with antiviral drugs or resorting to a caesarean section in some specific cases.
Infection with herpes simplex is one of the most common sexually transmitted infections. Because the infection is common in women of reproductive age it can be contracted and transmitted to the fetus during pregnancy and the newborn. Herpes simplex virus is an important cause of neonatal infection, which can lead to death or long-term disabilities. Rarely in the uterus, it occurs frequently during the transmission delivery. The greatest risk of transmission to the fetus and the newborn occurs in case of an initial maternal infection contracted in the second half of pregnancy. The risk of transmission of maternal-fetal-neonatal herpes simplex can be decreased by performing a treatment with antiviral drugs or resorting to a caesarean section in some specific cases.
Herpes simplex virus (HSV) قسم 1 ۽ 2 دنيا جي ڪيترن ئي ماڻهن کي متاثر ڪن ٿا. عام طور تي، وائرس چمڙي کي متاثر ڪرڻ کان پوء اعصاب خاني ۾ خاموش رهي ٿو، پر اهو بعد ۾ ٻيهر فعال ٿي سگهي ٿو، ٿڌي زخم جو سبب بڻائيندو. ڪڏهن ڪڏهن، اهو سنگين مسئلن جهڙوڪ اکين جي انفيڪشن، دماغ جي سوزش، يا نوزائشي ۽ ڪمزور مدافعتي نظام رکندڙ ماڻهن ۾ خطرناڪ حالتن جي ڪري ٿي. جڏهن ته موجوده دوائون انفيڪشن کي ڪنٽرول ڪرڻ ۾ مدد ڪن ٿيون، منشيات جي مزاحمت ۽ ضمني اثرات جو خطرو رهي ٿو. اسان کي وائرس کي بهتر نشانو بڻائڻ لاءِ نئين دوائن جي ضرورت آهي.
Infection with herpes simplex virus (HSV) types 1 and 2 is ubiquitous in the human population. Most commonly, virus replication is limited to the epithelia and establishes latency in enervating sensory neurons, reactivating periodically to produce localized recurrent lesions. However, these viruses can also cause severe disease such as recurrent keratitis leading potentially to blindness, as well as encephalitis, and systemic disease in neonates and immunocompromised patients. Although antiviral therapy has allowed continual and substantial improvement in the management of both primary and recurrent infections, resistance to currently available drugs and long-term toxicity pose a current and future threat that should be addressed through the development of new antiviral compounds directed against new targets.
Infection with herpes simplex virus (HSV) types 1 and 2 is ubiquitous in the human population. Most commonly, virus replication is limited to the epithelia and establishes latency in enervating sensory neurons, reactivating periodically to produce localized recurrent lesions. However, these viruses can also cause severe disease such as recurrent keratitis leading potentially to blindness, as well as encephalitis, and systemic disease in neonates and immunocompromised patients. Although antiviral therapy has allowed continual and substantial improvement in the management of both primary and recurrent infections, resistance to currently available drugs and long-term toxicity pose a current and future threat that should be addressed through the development of new antiviral compounds directed against new targets.
هتي ٻه قسم آهن هرپس سمپلڪس (herpes simplex) وائرس، ٽائپ 1 (HSV-1) ۽ ٽائپ 2 (HSV-2). HSV-1 وڌيڪ عام طور تي وات جي چوڌاري انفيڪشن جو سبب بڻائيندو آهي جڏهن ته HSV-2 وڌيڪ عام طور تي جينياتي انفيڪشن جو سبب بڻائيندو آهي. اهي متاثر ٿيل فرد سان سڌي رابطي ذريعي منتقل ڪيا ويا آهن. جينياتي هيپس هڪ جنسي طور تي منتقل ٿيل انفيڪشن جي طور تي درجه بندي ڪئي وئي آهي. اهو ٻار جي ڄمڻ دوران هڪ ٻار ۾ پکڙيل ٿي سگهي ٿو. انفيڪشن کان پوء، وائرس حساس اعصاب سان گڏ اعصاب سيل جسم ڏانهن منتقل ڪيا ويا آهن، جتي اهي زندگي گذاريندا آهن. ٻيهر ٿيڻ جي سببن ۾ شامل ٿي سگھي ٿو: گھٽتائي مدافعتي ڪارڪردگي، دٻاء، ۽ سج جي روشني جي نمائش.
اڪثر ڪيسن ۾، اينٽي وائرل دوائون صرف ان صورت ۾ ورتيون وينديون آهن جڏهن علامتون سخت هجن. روزاني اينٽي وائرل دوا ڪنهن ماڻهو لاءِ تجويز ڪري سگهجي ٿي جنهن کي تمام گهڻو انفيڪشن آهي. ڪا به ويڪسين موجود ناهي ۽ شنگلز جي ويڪسين هرپس سادوڪس کي روڪي نه ٿي. اينٽي وائرل دوائن سان علاج جهڙوڪ aciclovir يا valaciclovir علامتن جي شدت کي گهٽائي سگهن ٿا.
HSV-1 يا HSV-2 جي عالمي شرح بالغن ۾ 60٪ ۽ 95٪ جي وچ ۾ آهن. HSV-1 عام طور تي ننڍپڻ دوران متاثر ٿيندو آهي. هڪ اندازي مطابق سڄي دنيا ۾ 536 ملين ماڻهو (آبادي جو 16 سيڪڙو) 2003 تائين HSV-2 سان متاثر ٿيا جن ۾ عورتن ۽ ترقي پذير دنيا ۾ ان جي شرح وڌيڪ هئي. HSV-2 سان گهڻا ماڻهو اهو نه ٿا سمجهن ته اهي متاثر ٿيل آهن.
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